Characterization of the metallo-dependent amidohydrolases responsible for “auxiliary” leucinyl removal in the biosynthesis of 2,2′-bipyridine antibiotics

Characterization of the metallo-dependent amidohydrolases responsible for “auxiliary” leucinyl removal in the biosynthesis of 2,2′-bipyridine antibiotics

2,2′-Bipyridine (2,2′-BiPy) is an attractive core structure present in a number of biologically active natural products, including the structurally related antibiotics caerulomycins (CAEs) and collismycins (COLs). Their biosynthetic pathways share a similar key 2,2′-BiPy-l-leucine intermediate, whic...

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Bibliographic Details
Main Authors: Ming Chen, Bo Pang, Ya-nan Du, Yi-peng Zhang, Wen Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
2,2′-Bipyridine antibiotics
Caerulomycins
Collismycins
Amidohydrolase
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X17300522

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http://www.sciencedirect.com/science/article/pii/S2405805X17300522

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