Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA

Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA

Abstract The characteristics of IDH-wild-type lower-grade astrocytoma remain unclear. According to cIMPACT-NOW update 3, IDH-wild-type astrocytomas with any of the following factors show poor prognosis: combination of chromosome 7 gain and 10 loss (+ 7/− 10), and/or EGFR amplification, and/or TERT p...

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Bibliographic Details
Main Authors: Yasuhide Makino, Yoshiki Arakawa, Ema Yoshioka, Tomoko Shofuda, Takeshi Kawauchi, Yukinori Terada, Masahiro Tanji, Daisuke Kanematsu, Yohei Mineharu, Susumu Miyamoto, Yonehiro Kanemura
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93937-8

Internet

https://doi.org/10.1038/s41598-021-93937-8

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