Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.

Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of a hypertensive agent and an endothelin receptor A antagonist drugs would limit...

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Bibliographic Details
Main Authors: Daniel Radiloff, Yulin Zhao, Alina Boico, Gert Blueschke, Gregory Palmer, Andrew Fontanella, Mark Dewhirst, Claude A Piantadosi, Robert Noveck, David Irwin, Karyn Hamilton, Bruce Klitzman, Thies Schroeder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4068990?pdf=render