Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer

Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer

Abstract Background Gastric cancer (GC) is a common form of malignant cancer in worldwide which has a poor prognosis. Despite recent improvements in the treatment of GC, the prognosis is not yet satisfactory for GC patients. CYT997, a novel microtubule-targeting agent, recently has been identified t...

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Bibliographic Details
Main Authors: Ya Cao, Jinglong Wang, Hua Tian, Guo-Hui Fu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CYT997
ROS
JAK2/STAT3
Apoptosis
Gastric cancer
Online Access:http://link.springer.com/article/10.1186/s13046-020-01621-y

Internet

http://link.springer.com/article/10.1186/s13046-020-01621-y

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