Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells

Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells

Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption that pore formation in the cell membrane is responsible for increased uptake...

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Bibliographic Details
Main Authors: Ragnhild Haugse, Anika Langer, Stein-Erik Gullaksen, Silje Maria Sundøy, Bjørn Tore Gjertsen, Spiros Kotopoulis, Emmet McCormack
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Pharmaceutics
Subjects:
sonoporation
microbubbles
ultrasound
intracellular signaling
phosphorylation
ultrasound contrast agents
drug delivery
cellular stress
Online Access:https://www.mdpi.com/1999-4923/11/7/319

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https://www.mdpi.com/1999-4923/11/7/319

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