Preimplantation Genetic Testing for Polygenic Disease Relative Risk Reduction: Evaluation of Genomic Index Performance in 11,883 Adult Sibling Pairs

Preimplantation Genetic Testing for Polygenic Disease Relative Risk Reduction: Evaluation of Genomic Index Performance in 11,883 Adult Sibling Pairs

Preimplantation genetic testing for polygenic disease risk (PGT-P) represents a new tool to aid in embryo selection. Previous studies demonstrated the ability to obtain necessary genotypes in the embryo with accuracy equivalent to in adults. When applied to select adult siblings with known type I di...

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Bibliographic Details
Main Authors: Nathan R. Treff, Jennifer Eccles, Diego Marin, Edward Messick, Louis Lello, Jessalyn Gerber, Jia Xu, Laurent C. A. M. Tellier
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Genes
Subjects:
preimplantation genetic testing
PGT-P
polygenic risk scoring
genomic index
relative risk reduction
Online Access:https://www.mdpi.com/2073-4425/11/6/648

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https://www.mdpi.com/2073-4425/11/6/648

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