Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss

Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss

Abstract α-Synuclein is a protein involved in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). We investigated the role of neuronal α-Syn in myelin composition and abnormalities. The phospholipid content of...

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Bibliographic Details
Main Authors: Jessica Grigoletto, Katharina Pukaß, Ayelet Gamliel, Dana Davidi, Rachel Katz-Brull, Christiane Richter-Landsberg, Ronit Sharon
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Acta Neuropathologica Communications
Subjects:
α-Synuclein
Myelin
Phospholipids
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s40478-017-0439-3

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http://link.springer.com/article/10.1186/s40478-017-0439-3

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