Transient Microneedle Insertion into Hippocampus Triggers Neurogenesis and Decreases Amyloid Burden in a Mouse Model of Alzheimer's Disease

Targeted microlesions of the hippocampus have been reported to enhance neurogenesis in the subgranular zone (SGZ). The potential therapeutic impact of transient insertion of a microneedle was investigated in a mouse model of Alzheimer's disease (AD). We tested the hypothesis that transient micr...

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Bibliographic Details
Main Authors: Shijie Song M.D., Xiaoyung Kong, Vasyl Sava, Chuanhai Cao, Sandra Acosta, Cesar Borlongan, Juan Sanchez-Ramos Ph.D., M.D.
Format: Article
Language:English
Published: SAGE Publishing 2016-10-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368916X691114