The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

At present, there are no effective antifibrotic drugs for patients with chronic liver disease; hence, the development of antifibrotic therapies is urgently needed. Here, we performed an experimental and translational study to investigate the potential and underlying mechanism of quercetin treatment...

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Bibliographic Details
Main Authors: Xi Li, Qianwen Jin, Qunyan Yao, Beili Xu, Lixin Li, Shuncai Zhang, Chuantao Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
hepatic fibrosis
quercetin
macrophages
polarization
Notch1
hepatic stellate cells (HSCs)
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00072/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00072/full

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