Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN)

Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN)

Translation is spatiotemporally regulated and endoplasmic reticulum (ER)-associated mRNAs are generally in efficient translation. It is unclear whether the ER-associated mRNAs are deadenylated or degraded on the ER surface in situ or in the cytosol. Here, we showed that ER possessed active deadenyla...

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Bibliographic Details
Main Authors: Tian-Li Duan, Han Jiao, Guang-Jun He, Yong-Bin Yan
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
deadenylation
dna damage response
er-anchored ribonuclease
er-associated mrnas
mrna decay
poly(a) length profile
poly(a)-specific ribonuclease
translation efficiency
Online Access:https://www.mdpi.com/2073-4409/9/1/162

Internet

https://www.mdpi.com/2073-4409/9/1/162

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