A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition

A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition

Abstract UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown. Here we show that a specific pharmacological inhibi...

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Bibliographic Details
Main Authors: Shojiro Kitajima, Wendi Sun, Kian Leong Lee, Jolene Caifeng Ho, Seiichi Oyadomari, Takashi Okamoto, Hisao Masai, Lorenz Poellinger, Hiroyuki Kato
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83857-y

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https://doi.org/10.1038/s41598-021-83857-y

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