The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis

The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis

The human paranasal sinuses are the major source of intrinsic nitric oxide (NO) production in the human airway. NO plays several roles in the maintenance of physiological homeostasis and the regulation of airway inflammation through the expression of three NO synthase (NOS) isoforms. Measuring NO le...

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Bibliographic Details
Main Authors: Tomohiro Kawasumi, Sachio Takeno, Chie Ishikawa, Daisuke Takahara, Takayuki Taruya, Kota Takemoto, Takao Hamamoto, Takashi Ishino, Tsutomu Ueda
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
nitric oxide (NO)
nitric oxide synthase
isoform
nasal NO
redox pathway
arginase
Online Access:https://www.mdpi.com/1422-0067/22/14/7561

Internet

https://www.mdpi.com/1422-0067/22/14/7561

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