Insights on the Structural Variations of the Furin-Like Cleavage Site Found Among the December 2019–July 2020 SARS-CoV-2 Spike Glycoprotein: A Computational Study Linking Viral Evolution and Infection

Insights on the Structural Variations of the Furin-Like Cleavage Site Found Among the December 2019–July 2020 SARS-CoV-2 Spike Glycoprotein: A Computational Study Linking Viral Evolution and Infection

The SARS-CoV-2 (SARS2) is the cause of the coronavirus disease 2019 (COVID-19) pandemic. One unique structural feature of the SARS2 spike protein is the presence of a furin-like cleavage site (FLC) which is associated with both viral pathogenesis and host tropism. Specifically, SARS2 spike protein b...

Full description

Bibliographic Details
Main Authors: Marni E. Cueno, Miu Ueno, Rinako Iguchi, Tsubasa Harada, Yoshifumi Miki, Kanae Yasumaru, Natsumi Kiso, Kanta Wada, Koki Baba, Kenichi Imai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Medicine
Subjects:
furin-like cleavage site
infection clusters
SARS-CoV-2 (SARS2)
spike glycoprotein
structural variations
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.613412/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.613412/full

Similar Items