A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

During class switch recombination (CSR), B cells replace the Igh Cμ or δ exons with another downstream constant region exon (CH), altering the antibody isotype. CSR occurs through the introduction of AID-mediated double-strand breaks (DSBs) in switch regions and subsequent ligation of broken ends. H...

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Bibliographic Details
Main Authors: Pedro P. Rocha, Ramya Raviram, Yi Fu, JungHyun Kim, Vincent M. Luo, Arafat Aljoufi, Emily Swanzey, Alessandra Pasquarella, Alessia Balestrini, Emily R. Miraldi, Richard Bonneau, John Petrini, Gunnar Schotta, Jane A. Skok
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306866

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http://www.sciencedirect.com/science/article/pii/S2211124716306866

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