Antiproliferative Effects of Cucurbitacin B in Breast Cancer Cells: Down-Regulation of the c-Myc/hTERT/Telomerase Pathway and Obstruction of the Cell Cycle

Antiproliferative Effects of Cucurbitacin B in Breast Cancer Cells: Down-Regulation of the c-Myc/hTERT/Telomerase Pathway and Obstruction of the Cell Cycle

Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from the Thai herb Trichosanthes cucumerina L. on telomerase regulation in three human breast cancer cell lines (...

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Bibliographic Details
Main Authors: Suwit Duangmano, Sumana Dakeng, Weena Jiratchariyakul, Apichart Suksamrarn, Duncan R. Smith, Pimpicha Patmasiriwat
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:International Journal of Molecular Sciences
Subjects:
cucurbitacin B
telomerase
hTERT
c-Myc
breast cancer
estrogen receptor
Online Access:http://www.mdpi.com/1422-0067/11/12/5323/

Internet

http://www.mdpi.com/1422-0067/11/12/5323/

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