Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases

Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases

Aberrant activations of the STAT3 (signal transducer and activator of transcription 3) signaling pathway are associated with cancer and inflammatory diseases. Three of the four Janus kinases, JAK1, JAK2, and Tyk2, are the major upstream kinases of STAT3 in responses to cytokine stimulations. Among t...

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Bibliographic Details
Main Authors: Man Liu, Chengqian Xiao, Mingwei Sun, Minjia Tan, Lihong Hu, Qiang Yu
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
parthenolide
covalent inhibitor
cell death
JAK/STAT3 signaling
Online Access:http://www.mdpi.com/1420-3049/23/6/1478

Internet

http://www.mdpi.com/1420-3049/23/6/1478

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