Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.

Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.

Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate...

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Bibliographic Details
Main Authors: Marta Stasiak, Joanna Boncela, Corinne Perreau, Konstantina Karamanou, Aurore Chatron-Colliet, Isabelle Proult, Patrycja Przygodzka, Shukti Chakravarti, François-Xavier Maquart, M Anna Kowalska, Yanusz Wegrowski, Stéphane Brézillon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4773148?pdf=render

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http://europepmc.org/articles/PMC4773148?pdf=render

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