Elucidation of the Activation Pathways of ScyA1/ScyR1, an Aco/ArpA-Like System That Regulates the Expression of Nemadectin and Other Secondary Metabolic Biosynthetic Genes

Elucidation of the Activation Pathways of ScyA1/ScyR1, an Aco/ArpA-Like System That Regulates the Expression of Nemadectin and Other Secondary Metabolic Biosynthetic Genes

The quorum-sensing system, consisting of an autoregulator synthase (AfsA or Aco homolog) and an autoregulator receptor (ArpA homolog), has been reported to be universally involved in regulating secondary metabolism in streptomycetes. Although the autoregulator synthase is thought to activate antibio...

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Bibliographic Details
Main Authors: Hui Liu, Yanyan Zhang, Shanshan Li, Jiabin Wang, Xiangjing Wang, Wensheng Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
nemadectin
activation pathway
ScyA1/ScyR1
Streptomyces cyaneogriseus ssp. noncyanogenus
autoregulator synthase
quorum-sensing system
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.589730/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2020.589730/full

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