Protease activated receptor-2 contributes to heart failure.

Heart failure is a major clinical problem worldwide. Previous studies have demonstrated an important role for G protein-coupled receptors, including protease-activated receptors (PARs), in the pathology of heart hypertrophy and failure. Activation of PAR-2 on cardiomyocytes has been shown to induce...

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Bibliographic Details
Main Authors: Silvio Antoniak, Erica M Sparkenbaugh, Michael Tencati, Mauricio Rojas, Nigel Mackman, Rafal Pawlinski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842269?pdf=render