Examination and characterisation of the effect of amitriptyline therapy for chronic neuropathic pain on neuropeptide and proteomic constituents of human cerebrospinal fluid

Examination and characterisation of the effect of amitriptyline therapy for chronic neuropathic pain on neuropeptide and proteomic constituents of human cerebrospinal fluid

Introduction: Amitriptyline is prescribed to reduce the intensity of chronic neuropathic pain. There is a paucity of validated in vivo evidence in humans regarding amitriptyline’s mechanism of action. We examined the effect of amitriptyline therapy on cerebrospinal fluid (CSF) neuropeptides and prot...

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Bibliographic Details
Main Authors: Jonathan Royds, Hilary Cassidy, Melissa J. Conroy, Margaret R. Dunne, Joanne Lysaght, Connail McCrory
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Amitriptyline
Mechanism of action
Cerebrospinal fluid
Neuropathic pain
Neuroimmune
Neuropharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620301496

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http://www.sciencedirect.com/science/article/pii/S2666354620301496

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