Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

Objectives: Receptor Activity-Modifying Protein 2 (RAMP2) is a chaperone protein which allosterically binds to and interacts with the glucagon receptor (GCGR). The aims of this study were to investigate the effects of RAMP2 on GCGR trafficking and signalling in the liver, where glucagon (GCG) is imp...

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Bibliographic Details
Main Authors: Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R. Bloom, Tricia Tan, Alejandra Tomas
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Glucagon receptor
Receptor activity-modifying protein 2
G protein-coupled receptors
Endocytic trafficking
Intracellular signalling
Carbohydrate metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001411

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http://www.sciencedirect.com/science/article/pii/S2212877821001411

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