Studies examining the synergy between Dihydrotanshinone and Temozolomide against MGMT+ glioblastoma cells in vitro: Predicting interactions with the blood-brain barrier

Studies examining the synergy between Dihydrotanshinone and Temozolomide against MGMT+ glioblastoma cells in vitro: Predicting interactions with the blood-brain barrier

We showed previously that Dihydrotanshinone (DHT) augments temozolomide (TMZ) efficacy by inducing reactive oxygen species production in an in vitro model. Here, the underlying basis of the synergistic effect and the ability of DHT to potentially pass the blood brain barrier (BBB) is investigated us...

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Bibliographic Details
Main Authors: Varun Kumar, Daniel Radin, Donna Leonardi
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Blood-brain barrier
Dihydrotanshinone
Glioblastoma
NFkB
Synergy
Temozolomide
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218349266

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http://www.sciencedirect.com/science/article/pii/S0753332218349266

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