Neuroinflammation as a Therapeutic Target for Mitigating the Long-Term Consequences of Acute Organophosphate Intoxication

Neuroinflammation as a Therapeutic Target for Mitigating the Long-Term Consequences of Acute Organophosphate Intoxication

Acute intoxication with organophosphates (OPs) can cause a potentially fatal cholinergic crisis characterized by peripheral parasympathomimetic symptoms and seizures that rapidly progress to status epilepticus (SE). While current therapeutic countermeasures for acute OP intoxication significantly im...

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Bibliographic Details
Main Authors: Peter M. Andrew, Pamela J. Lein
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
acquired epilepsy
astrocytes
cognitive impairment
functional polarization
microglia
glial cell activation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.674325/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.674325/full

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