A Novel One-Pot Enzyme Cascade for the Biosynthesis of Cladribine Triphosphate

A Novel One-Pot Enzyme Cascade for the Biosynthesis of Cladribine Triphosphate

Cladribine triphosphate is the active compound of the anti-cancer and multiple sclerosis drug Mavenclad (cladribine). Biosynthesis of such non-natural deoxyribonucleotides is challenging but important in order to study the pharmaceutical modes of action. In this study, we developed a novel one-pot e...

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Bibliographic Details
Main Authors: Julia Frisch, Tin Maršić, Christoph Loderer
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
enzymatic nucleotide synthesis
enzymatic cascade synthesis
deoxyribonucleoside-5´-triphosphate
nucleotide analogue
adenine phosphoribosyltransferase
polyphosphate kinase
Online Access:https://www.mdpi.com/2218-273X/11/3/346

Internet

https://www.mdpi.com/2218-273X/11/3/346

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