Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides

Objectives: Most DAMPs in inflammatory diseases are TLR2- and TLR4-ligands and according to the current concept, repeated stimuli would result in tolerance. Aims of the study were to verify this assumption, to investigate whether epigenetic effectors are involved and to explore the situation in rheu...

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Bibliographic Details
Main Authors: Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
trained immunity
DAMPs
S100A4 protein
epigenetic
rheumatoid arthritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00791/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00791/full

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