Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production

Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity. However, insights into the role of CFH in B cell biology are limited. Here, we dem...

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Bibliographic Details
Main Authors: Máté G. Kiss, Mária Ozsvár-Kozma, Florentina Porsch, Laura Göderle, Nikolina Papac-Miličević, Barbara Bartolini-Gritti, Dimitrios Tsiantoulas, Matthew C. Pickering, Christoph J. Binder
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
complement factor H
complement
autoimmunity
B cell development
B cell receptor signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01607/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01607/full

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