Effects of the Oncoprotein PAX3-FOXO1 on Modulation of Exosomes Function and Protein Content: Implications on Oxidative Stress Protection and Enhanced Plasticity

Effects of the Oncoprotein PAX3-FOXO1 on Modulation of Exosomes Function and Protein Content: Implications on Oxidative Stress Protection and Enhanced Plasticity

Rhabdomyosarcoma (RMS) is a highly malignant soft tissue sarcoma classified into two major histologic subtypes: embryonal (ERMS) and alveolar (ARMS). ARMS subtype is clinically more aggressive, and characterized by an oncogenic fusion protein PAX3-FOXO1 (P3F) that drives oncogenic cellular propertie...

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Bibliographic Details
Main Authors: Assil Fahs, Farah Ramadan, Farah Ghamloush, Abeer J. Ayoub, Fatima Ali Ahmad, Firas Kobeissy, Yehia Mechref, Jingfu Zhao, Rui Zhu, Nader Hussein, Raya Saab, Sandra E. Ghayad
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
Rhabdomyosarcoma
PAX3-FOXO1
exosomes
oxidative stress
plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01784/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01784/full

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