An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22465-w |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sia Viborg Lindskrog Frederik Prip Philippe Lamy Ann Taber Clarice S. Groeneveld Karin Birkenkamp-Demtröder Jørgen Bjerggaard Jensen Trine Strandgaard Iver Nordentoft Emil Christensen Mateo Sokac Nicolai J. Birkbak Lasse Maretty Gregers G. Hermann Astrid C. Petersen Veronika Weyerer Marc-Oliver Grimm Marcus Horstmann Gottfrid Sjödahl Mattias Höglund Torben Steiniche Karin Mogensen Aurélien de Reyniès Roman Nawroth Brian Jordan Xiaoqi Lin Dejan Dragicevic Douglas G. Ward Anshita Goel Carolyn D. Hurst Jay D. Raman Joshua I. Warrick Ulrika Segersten Danijel Sikic Kim E. M. van Kessel Tobias Maurer Joshua J. Meeks David J. DeGraff Richard T. Bryan Margaret A. Knowles Tatjana Simic Arndt Hartmann Ellen C. Zwarthoff Per-Uno Malmström Núria Malats Francisco X. Real Lars Dyrskjøt |
| spellingShingle |
Sia Viborg Lindskrog Frederik Prip Philippe Lamy Ann Taber Clarice S. Groeneveld Karin Birkenkamp-Demtröder Jørgen Bjerggaard Jensen Trine Strandgaard Iver Nordentoft Emil Christensen Mateo Sokac Nicolai J. Birkbak Lasse Maretty Gregers G. Hermann Astrid C. Petersen Veronika Weyerer Marc-Oliver Grimm Marcus Horstmann Gottfrid Sjödahl Mattias Höglund Torben Steiniche Karin Mogensen Aurélien de Reyniès Roman Nawroth Brian Jordan Xiaoqi Lin Dejan Dragicevic Douglas G. Ward Anshita Goel Carolyn D. Hurst Jay D. Raman Joshua I. Warrick Ulrika Segersten Danijel Sikic Kim E. M. van Kessel Tobias Maurer Joshua J. Meeks David J. DeGraff Richard T. Bryan Margaret A. Knowles Tatjana Simic Arndt Hartmann Ellen C. Zwarthoff Per-Uno Malmström Núria Malats Francisco X. Real Lars Dyrskjøt An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer Nature Communications |
| author_facet |
Sia Viborg Lindskrog Frederik Prip Philippe Lamy Ann Taber Clarice S. Groeneveld Karin Birkenkamp-Demtröder Jørgen Bjerggaard Jensen Trine Strandgaard Iver Nordentoft Emil Christensen Mateo Sokac Nicolai J. Birkbak Lasse Maretty Gregers G. Hermann Astrid C. Petersen Veronika Weyerer Marc-Oliver Grimm Marcus Horstmann Gottfrid Sjödahl Mattias Höglund Torben Steiniche Karin Mogensen Aurélien de Reyniès Roman Nawroth Brian Jordan Xiaoqi Lin Dejan Dragicevic Douglas G. Ward Anshita Goel Carolyn D. Hurst Jay D. Raman Joshua I. Warrick Ulrika Segersten Danijel Sikic Kim E. M. van Kessel Tobias Maurer Joshua J. Meeks David J. DeGraff Richard T. Bryan Margaret A. Knowles Tatjana Simic Arndt Hartmann Ellen C. Zwarthoff Per-Uno Malmström Núria Malats Francisco X. Real Lars Dyrskjøt |
| author_sort |
Sia Viborg Lindskrog |
| title |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_short |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_full |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_fullStr |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_full_unstemmed |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_sort |
integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes. |
| url |
https://doi.org/10.1038/s41467-021-22465-w |
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| _version_ |
1721522590001922048 |
| spelling |
doaj-25de5d15c38f4468b633c9e4bdca4e8d2021-04-18T11:12:32ZengNature Publishing GroupNature Communications2041-17232021-04-0112111810.1038/s41467-021-22465-wAn integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancerSia Viborg Lindskrog0Frederik Prip1Philippe Lamy2Ann Taber3Clarice S. Groeneveld4Karin Birkenkamp-Demtröder5Jørgen Bjerggaard Jensen6Trine Strandgaard7Iver Nordentoft8Emil Christensen9Mateo Sokac10Nicolai J. Birkbak11Lasse Maretty12Gregers G. Hermann13Astrid C. Petersen14Veronika Weyerer15Marc-Oliver Grimm16Marcus Horstmann17Gottfrid Sjödahl18Mattias Höglund19Torben Steiniche20Karin Mogensen21Aurélien de Reyniès22Roman Nawroth23Brian Jordan24Xiaoqi Lin25Dejan Dragicevic26Douglas G. Ward27Anshita Goel28Carolyn D. Hurst29Jay D. Raman30Joshua I. Warrick31Ulrika Segersten32Danijel Sikic33Kim E. M. van Kessel34Tobias Maurer35Joshua J. Meeks36David J. DeGraff37Richard T. Bryan38Margaret A. Knowles39Tatjana Simic40Arndt Hartmann41Ellen C. Zwarthoff42Per-Uno Malmström43Núria Malats44Francisco X. Real45Lars Dyrskjøt46Department of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalCartes d’Identité des Tumeurs (CIT) Program, Ligue Nationale Contre le CancerDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Clinical Medicine, Aarhus UniversityDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Molecular Medicine, Aarhus University HospitalDepartment of Urology, Herlev hospital, Copenhagen UniversityDepartment of Pathology, Aalborg University HospitalInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Urology, Jena University HospitalDepartment of Urology, Jena University HospitalDivision of Urological Research, Department of Translational Medicine, Lund University, Skåne University HospitalDivision of Oncology and Pathology, Department of Clinical Sciences, Lund UniversityDepartment of Pathology, Aarhus University HospitalDepartment of Urology, Herlev hospital, Copenhagen UniversityCartes d’Identité des Tumeurs (CIT) Program, Ligue Nationale Contre le CancerDepartment of Urology, Technical University of Munich, Klinikum rechts der IsarDepartments of Pathology, Urology, Biochemistry and Molecular Genetics, Northwestern University School of MedicineDepartments of Pathology, Urology, Biochemistry and Molecular Genetics, Northwestern University School of MedicineClinic of Urology, Clinical Centre of Serbia, Faculty of Medicine, University of BelgradeBladder Cancer Research Centre, Institute of Cancer and Genomic Sciences, College of Medicine and Dental Sciences, University of BirminghamBladder Cancer Research Centre, Institute of Cancer and Genomic Sciences, College of Medicine and Dental Sciences, University of BirminghamLeeds Institute of Medical Research at St James’s, University of LeedsDepartment of Surgery, Division of Urology, Pennsylvania State UniversityDepartment of Pathology and Laboratory Medicine, Division of Urology, Department of Biochemistry and Molecular Biology, Pennsylvania State UniversityDepartment of Surgical Sciences, Uppsala UniversityDepartment of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical CenterDepartment of Urology, Technical University of Munich, Klinikum rechts der IsarDepartments of Pathology, Urology, Biochemistry and Molecular Genetics, Northwestern University School of MedicineDepartment of Pathology and Laboratory Medicine, Division of Urology, Department of Biochemistry and Molecular Biology, Pennsylvania State UniversityBladder Cancer Research Centre, Institute of Cancer and Genomic Sciences, College of Medicine and Dental Sciences, University of BirminghamLeeds Institute of Medical Research at St James’s, University of LeedsInstitute of Medical and Clinical Biochemistry, Faculty of Medicine, University of BelgradeInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical CenterDepartment of Surgical Sciences, Uppsala UniversityGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), CIBERONCEpithelial Carcinogenesis Group, Spanish National Cancer Research Center (CNIO)Department of Molecular Medicine, Aarhus University HospitalMultiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes.https://doi.org/10.1038/s41467-021-22465-w |