A controlled release bupivacaine-alginate construct: Effect on chondrocyte hypertrophy conversion

A controlled release bupivacaine-alginate construct: Effect on chondrocyte hypertrophy conversion

Objective: Osteoarthritis is a degenerative disease of the joint, affecting over 30 million people in the US1. A key characteristic of OA is chondrocyte hypertrophy, characterized by chondrocyte changes to a more rounded and osteoblastic phenotype, characterized by increased IL-6 and IL-8 secretion2...

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Bibliographic Details
Main Authors: Mollie S. Davis, Ileana Marrero – Berrios, Xiomara I. Perez, Palangat Radhakrishnan, Devasena Manchikalapati, Khaja Ahmed, Hattiyangangadi Kamath, Rene S. Schloss, Joel Yarmush
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Chondrocyte inflammation
Local anesthetics
Sustained release
Chondrocyte hypertrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913120301254

Internet

http://www.sciencedirect.com/science/article/pii/S2665913120301254

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