Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine ModelsSummary

Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine ModelsSummary

Background & Aims: Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied. In this study, we aimed to investigate the po...

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Bibliographic Details
Main Authors: Jiro Kusakabe, Koichiro Hata, Hidetaka Miyauchi, Tetsuya Tajima, Yi Wang, Ichiro Tamaki, Junya Kawasoe, Yusuke Okamura, Xiangdong Zhao, Tatsuya Okamoto, Tatsuaki Tsuruyama, Shinji Uemoto
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Eculizumab
Anaphylatoxin
Membrane Attack Complex (MAC: C5b-9)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21000011

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http://www.sciencedirect.com/science/article/pii/S2352345X21000011

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