Pervasive Inter-Individual Variation in Allele-Specific Expression in Monozygotic Twins

Pervasive Inter-Individual Variation in Allele-Specific Expression in Monozygotic Twins

Despite being developed from one zygote, heterokaryotypic monozygotic (MZ) co-twins exhibit discordant karyotypes. Epigenomic studies in biological samples from heterokaryotypic MZ co-twins are of the most significant value for assessing the effects on gene- and allele-specific expression of an extr...

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Bibliographic Details
Main Authors: Ronaldo da Silva Francisco Junior, Cristina dos Santos Ferreira, Juan Carlo Santos e Silva, Douglas Terra Machado, Yasmmin Côrtes Martins, Victor Ramos, Gustavo Simões Carnivali, Ana Beatriz Garcia, Enrique Medina-Acosta
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
allele-specific expression
allele imbalance
Down syndrome
genomic imprinting
heterokaryotypic monozygotic co-twins
mitochondrial heteroplasmy
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01178/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.01178/full

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