Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

Diabetes is associated with a high risk of developing cognitive dysfunction and neuropsychiatric disabilities, and these disease symptomsare termed diabetic encephalopathy (DEP). Inflammation is involved in the development of DEP. The cleavage and maturation of the proinflammatory cytokine interleuk...

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Bibliographic Details
Main Authors: Yadong Zhai, Xiangbao Meng, Tianyuan Ye, Weijie Xie, Guibo Sun, Xiaobo Sun
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
diabetic encephalopathy
NLRP3 inflammasome
MCC950
interleukin-1β
Online Access:http://www.mdpi.com/1420-3049/23/3/522

Internet

http://www.mdpi.com/1420-3049/23/3/522

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