Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/− and apoE−/− mice

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/− and apoE−/− mice

The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR−/−) or apolipoprotein E (apoE−/−) female or male mice were fed a Western diet and treated with a potent synthetic FXR agonist, WAY-362450. Activation of FXR blocked diet-induced hy...

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Bibliographic Details
Main Authors: Helen B. Hartman, Stephen J. Gardell, Chris J. Petucci, Shuguang Wang, Julie A. Krueger, Mark J. Evans
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Journal of Lipid Research
Subjects:
small heterodimer partner
cholesterol 7α-hydroxylase
sterol 12 α-hydroxylase
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308075

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http://www.sciencedirect.com/science/article/pii/S0022227520308075

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