DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION

DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION

Background: Donor natural killer (NK) cell alloreactivity in umbilical cord bone marrow transplantation (UCBT) can lead to leukemic relapse. However, NK cell function is calibrated by interaction with human leukocyte antigens (HLAs). This study aimed to investigate graft-resistant leukemia after tr...

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Bibliographic Details
Main Authors: xinchen fang, Zimin Sun, Huilan Liu, Xiang Wan, Wen Yao, Kaidi Song, Baolin Tang, Xiaoyu zhu, Jun Peng
Format: Article
Language:English
Published: PAGEPress Publications 2021-01-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
acute myeloid leukemia, natural killer cells, killer immunoglobulin-like receptors, umbilical cord blood transplantation，acute lymphocytic leukemia
Online Access:http://www.mjhid.org/index.php/mjhid/article/view/4363

Internet

http://www.mjhid.org/index.php/mjhid/article/view/4363

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