CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16

CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16

The insulin-like signaling pathway maintains a relatively short wild-type lifespan in Caenorhabditis elegans by phosphorylating and inactivating DAF-16, the ortholog of the FOXO transcription factors of mammalian cells. DAF-16 is phosphorylated by the AKT kinases, preventing its nuclear translocatio...

Full description

Bibliographic Details
Main Authors: Li Tao, Qi Xie, Yue-He Ding, Shang-Tong Li, Shengyi Peng, Yan-Ping Zhang, Dan Tan, Zengqiang Yuan, Meng-Qiu Dong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-06-01
Series:eLife
Subjects:
aging
lifespan
FOXO
CAMKII
calcineurin
DAF-16
Online Access:https://elifesciences.org/articles/00518

Internet

https://elifesciences.org/articles/00518

Similar Items