Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial for both neuronal and cardiac excitability....

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Bibliographic Details
Main Authors: Aldo A Rodríguez Menchaca, Scott K Adney, Lei eZhou, Diomedes E Logothetis
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00170/full