Immobilization of Neutral Protease from Bacillus subtilis for Regioselective Hydrolysis of Acetylated Nucleosides: Application to Capecitabine Synthesis

Immobilization of Neutral Protease from Bacillus subtilis for Regioselective Hydrolysis of Acetylated Nucleosides: Application to Capecitabine Synthesis

This paper describes the immobilization of the neutral protease from Bacillus subtilis and its application in the regioselective hydrolysis of acetylated nucleosides, including building blocks useful for the preparation of anticancer products. Regarding the immobilization study, different results ha...

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Bibliographic Details
Main Authors: Teodora Bavaro, Giulia Cattaneo, Immacolata Serra, Ilaria Benucci, Massimo Pregnolato, Marco Terreni
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
protease N
immobilization
nucleosides
regioselective hydrolysis
anticancer products
capecitabine
Online Access:http://www.mdpi.com/1420-3049/21/12/1621

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