Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1

Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1

Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening infectious disease caused by a novel phlebovirus, SFTS virus (SFTSV). Currently, there is no vaccine or antiviral available and the viral pathogenesis remains largely unknown. In this study, we demonstrated that SFTSV infection...

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Bibliographic Details
Main Authors: Yun-Jia Ning, Qiong Mo, Kuan Feng, Yuan-Qin Min, Mingyue Li, Dianhai Hou, Cheng Peng, Xin Zheng, Fei Deng, Zhihong Hu, Hualin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
IFN-γ
antiviral immunity
STAT1
severe fever with thrombocytopenia syndrome virus (SFTSV)
NSs
inclusion body
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01182/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01182/full

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