Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play

Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play

Etoposide is a semi-synthetic glycoside derivative of podophyllotoxin, also known as VP-16. It is a widely used anticancer medicine in clinics. Unfortunately, high doses or long-term etoposide treatment can induce therapy-related leukemia. The mechanism by which etoposide induces secondary hematopoi...

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Bibliographic Details
Main Authors: Wenchao Zhang, Panhong Gou, Jean-Marie Dupret, Christine Chomienne, Fernando Rodrigues-Lima
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Translational Oncology
Subjects:
Topoisomerase II poison
Etoposide
Oxidative metabolite
Double-stranded breaks
Therapy-related leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001613

Internet

http://www.sciencedirect.com/science/article/pii/S1936523321001613

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