RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.

Bibliographic Details
Main Authors:	Pamela Valnegri, Ju Huang, Tomoko Yamada, Yue Yang, Luis A. Mejia, Ha Y. Cho, Anna Oldenborg, Azad Bonni
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01333-6

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spelling	doaj-2525626ed6774066921db5fb8eb36a6f2021-05-11T07:18:07ZengNature Publishing GroupNature Communications2041-17232017-11-018111510.1038/s41467-017-01333-6RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brainPamela Valnegri0Ju Huang1Tomoko Yamada2Yue Yang3Luis A. Mejia4Ha Y. Cho5Anna Oldenborg6Azad Bonni7Department of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineUbiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.https://doi.org/10.1038/s41467-017-01333-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pamela Valnegri Ju Huang Tomoko Yamada Yue Yang Luis A. Mejia Ha Y. Cho Anna Oldenborg Azad Bonni
spellingShingle	Pamela Valnegri Ju Huang Tomoko Yamada Yue Yang Luis A. Mejia Ha Y. Cho Anna Oldenborg Azad Bonni RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain Nature Communications
author_facet	Pamela Valnegri Ju Huang Tomoko Yamada Yue Yang Luis A. Mejia Ha Y. Cho Anna Oldenborg Azad Bonni
author_sort	Pamela Valnegri
title	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_short	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_full	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_fullStr	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_full_unstemmed	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_sort	rnf8/ubc13 ubiquitin signaling suppresses synapse formation in the mammalian brain
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.
url	https://doi.org/10.1038/s41467-017-01333-6
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RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

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