RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01333-6 |