RNA–Protein Interactions Prevent Long RNA Duplex Formation: Implications for the Design of RNA-Based Therapeutics

RNA–Protein Interactions Prevent Long RNA Duplex Formation: Implications for the Design of RNA-Based Therapeutics

Cells frequently simultaneously express RNAs and cognate antisense transcripts without necessarily leading to the formation of RNA duplexes. Here, we present a novel transcriptome-wide experimental approach to ascertain the presence of accessible double-stranded RNA structures based on sequencing of...

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Bibliographic Details
Main Authors: Eckart Bindewald, Lisheng Dai, Wojciech K. Kasprzak, Taejin Kim, Shuo Gu, Bruce A. Shapiro
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
RNA–RNA
interaction
RNA-binding
RNA-binding protein (RBP)
ribosomal RNA (rRNA)
Dicer
helix
Online Access:https://www.mdpi.com/1420-3049/23/12/3329

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