Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting th...

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Main Authors:	John Tam, Therwa Hamza, Bing Ma, Kevin Chen, Greg L. Beilhartz, Jacques Ravel, Hanping Feng, Roman A. Melnyk
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07705-w

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spelling	doaj-25196c5f6826491d89346cd290d949ba2021-05-11T10:30:07ZengNature Publishing GroupNature Communications2041-17232018-12-019111110.1038/s41467-018-07705-wHost-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiotaJohn Tam0Therwa Hamza1Bing Ma2Kevin Chen3Greg L. Beilhartz4Jacques Ravel5Hanping Feng6Roman A. Melnyk7Molecular Medicine, Hospital for Sick ChildrenDepartment of Microbial Pathogenesis, University of Maryland Dental SchoolInstitute for Genome Sciences, University of Maryland School of MedicineDepartment of Microbial Pathogenesis, University of Maryland Dental SchoolMolecular Medicine, Hospital for Sick ChildrenInstitute for Genome Sciences, University of Maryland School of MedicineDepartment of Microbial Pathogenesis, University of Maryland Dental SchoolMolecular Medicine, Hospital for Sick ChildrenClostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting the gut microbiota.https://doi.org/10.1038/s41467-018-07705-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	John Tam Therwa Hamza Bing Ma Kevin Chen Greg L. Beilhartz Jacques Ravel Hanping Feng Roman A. Melnyk
spellingShingle	John Tam Therwa Hamza Bing Ma Kevin Chen Greg L. Beilhartz Jacques Ravel Hanping Feng Roman A. Melnyk Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota Nature Communications
author_facet	John Tam Therwa Hamza Bing Ma Kevin Chen Greg L. Beilhartz Jacques Ravel Hanping Feng Roman A. Melnyk
author_sort	John Tam
title	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_short	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_full	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_fullStr	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_full_unstemmed	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_sort	host-targeted niclosamide inhibits c. difficile virulence and prevents disease in mice without disrupting the gut microbiota
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-12-01
description	Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting the gut microbiota.
url	https://doi.org/10.1038/s41467-018-07705-w
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Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

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