Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma

Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma

Abstract Background TP53 gene mutations occur in more than 50% of human cancers and the vast majority of these mutations in human cancers are missense mutations, which broadly occur in DNA binding domain (DBD) (Amino acids 102–292) and mainly reside in six “hotspot” residues. TP53 G245C and R273H po...

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Bibliographic Details
Main Authors: Nan Kang, Yu Wang, Shichao Guo, Yunwei Ou, Guangchao Wang, Jie Chen, Dan Li, Qimin Zhan
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Cell Biology
Subjects:
Esophageal squamous cell carcinoma
TP53 mutation
Cell malignancy
Migration
Invasion
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12860-018-0167-y

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http://link.springer.com/article/10.1186/s12860-018-0167-y

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