Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative analysis of genome-scale CRISPR-Cas9 screens also i...

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Bibliographic Details
Main Authors: Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
KRAS
ERK
MYC
pancreatic cancer
BCAR1
p130Cas
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006628

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http://www.sciencedirect.com/science/article/pii/S2211124721006628

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