Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration

Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration

Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is characterized by loss of the retinal pigment epithelium (RPE). While the disease mechanism remains unclear, prior studies have linked AMD with RPE mitochondrial defects and genetic polymorphisms in the comple...

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Bibliographic Details
Main Authors: Mara C. Ebeling, Zhaohui Geng, Rebecca J. Kapphahn, Heidi Roehrich, Sandra R. Montezuma, James R. Dutton, Deborah A. Ferrington
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
induced pluripotent stem cell
retinal pigment epithelium
age-related macular degeneration
complement factor H
mitochondrial function
inflammation
Online Access:https://www.mdpi.com/2073-4409/10/4/789

Internet

https://www.mdpi.com/2073-4409/10/4/789

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