The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome

The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome

Dravet syndrome (DS) is a refractory epilepsy typically caused by heterozygous mutations of the Scn1a gene, which encodes the voltage-gated sodium channel Nav1.1. Glucagon-like peptide-1 (GLP-1) analogues, effective therapeutic agents for the treatment of diabetes, have recently become attractive tr...

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Bibliographic Details
Main Authors: Shenhai Liu, Zhe Jin, Yiling Zhang, ShiKuo Rong, Wenxin He, Kuisheng Sun, Din Wan, Junming Huo, Lifei Xiao, Xinxiao Li, Na Ding, Feng Wang, Tao Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
apoptosis
Dravet syndrome
epilepsy
GLP-1
mTOR
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00136/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00136/full

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