New Concept of the Biosynthesis of 4-Alkyl-L-proline Precursors of Lincomycin, Hormaomycin and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C-C Bond?

New Concept of the Biosynthesis of 4-Alkyl-L-proline Precursors of Lincomycin, Hormaomycin and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C-C Bond?

Structurally different and functionally diverse natural compounds – antitumour agents pyrrolo[1,4]benzodiazepines, bacterial hormone hormaomycin and lincosamide antibiotic lincomycin – share a common building unit, 4-alkyl-L-proline derivative (APD). APDs arise from L-tyrosine through a special bios...

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Bibliographic Details
Main Authors: Petra eJiraskova, Radek eGazak, Zdenek eKamenik, Lucie eSteiningerova, Lucie eNajmanova, Stanislav eKadlcik, Jitka eNovotna, Marek eKuzma, Jiri eJanata
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Microbiology
Subjects:
Actinobacteria
Lincomycin
Natural product biosynthesis
antibiotics
Enzyme mechanism
secondary metabolism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00276/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00276/full

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