Generation of Novel Traj18-Deficient Mice Lacking Vα14 Natural Killer T Cells with an Undisturbed T Cell Receptor α-Chain Repertoire.

Generation of Novel Traj18-Deficient Mice Lacking Vα14 Natural Killer T Cells with an Undisturbed T Cell Receptor α-Chain Repertoire.

Invariant Vα14 natural killer T (NKT) cells, characterized by the expression of a single invariant T cell receptor (TCR) α chain encoded by rearranged Trav11 (Vα14)-Traj18 (Jα18) gene segments in mice, and TRAV10 (Vα24)-TRAJ18 (Jα18) in humans, mediate adjuvant effects to activate various effector c...

Full description

Bibliographic Details
Main Authors: Nyambayar Dashtsoodol, Tomokuni Shigeura, Ritsuko Ozawa, Michishige Harada, Satoshi Kojo, Takashi Watanabe, Haruhiko Koseki, Manabu Nakayama, Osamu Ohara, Masaru Taniguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4827811?pdf=render

Internet

http://europepmc.org/articles/PMC4827811?pdf=render

Similar Items