Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors

Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors

Ataxia-telangiectasia (A-T) is a complex disease arising from mutations in the ATM gene (Ataxia-Telangiectasia Mutated), which plays crucial roles in repairing double-strand DNA breaks (DSBs). Heterogeneous immunodeficiency, extreme radiosensitivity, frequent appearance of tumors and neurological de...

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Bibliographic Details
Main Authors: Diana Carranza, Sara Torres-Rusillo, Gloria Ceballos-Pérez, Eva Blanco-Jimenez, Martin Muñoz-López, José L. García-Pérez, Ignacio J. Molina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
Ataxia-Telangiectasia
gene therapy
lentiviral vectors
monogenic diseases
cell reconstitution
Primary immunodeficiency
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02703/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02703/full

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